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We investigated with voltage-clamp experiments, effects of aqueous extracts (coffees) of unroasted and roasted coffee beans on the activity of human brain nicotinic acetylcholine receptor (nAChR) subtypes expressed in Xenopus oocytes, looking at complex brews, low molecular weight (LMW) fractions, and specific compounds present in coffee

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Oxidative stress conditions lead to vascular endothelial dysfunction, expression of redox-sensitive genes, induction of inflammation, and development of atherosclerosis [69]